Process for the preparation of N-maleoyl activated esters of ami

Details Process for the preparation of N-maleoyl activated esters of ami Process for the preparation of N-maleoyl activated esters of ami

1988-01-19

1990-12-25

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548548, C07D207452

Patent

active

049804820

ABSTRACT:
A process for the preparation of activated esters of certain N-maleoyl amino acids is disclosed. In the process, maleamic acids are cyclized and esterified to the desired products by the initial reaction with an acid halide reagent followed by a subsequent reaction with the appropriate hydroxyl-containing compound. The activated esters of N-maleoyl amino acids are particularly suited for linking compounds containing an amino group with those containing a thiol group.

REFERENCES:
patent: 3018292 (1962-01-01), Sauers
Yoshitake, "Conjugation of Glucose Oxidase . . . ", Eur J. Biochem 101, 395-399 (1979).

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