Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1989-09-26
1990-12-25
Berch, Mark L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
540363, 540364, C07D205085, C07D 4312, C07D41714, C07B 5100
Patent
active
049804650
ABSTRACT:
An improved process for making compounds having the formula ##STR1## includes subjecting an intermediate of the formula ##STR2## to hydrogenolysis in the presence of a ketonic solvent so as to simultaneously remove both Z-protecting groups from compound II while selectively reprotecting the --A.sub.1 --NH.sub.2 end of that molecule providing an intermediate of the formula ##STR3##
REFERENCES:
patent: 4743685 (1988-05-01), Breuer
patent: 4801705 (1989-06-01), Bruer
Godfrey Jr. Jollie D.
Mueller Richard H.
Zahler Robert
Berch Mark L.
E. R. Squibb & Sons Inc.
Furman Jr. Theodore R.
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