4-substituted-2-alkoxytetrahydrofuran derivatives

Details 4-substituted-2-alkoxytetrahydrofuran derivatives 4-substituted-2-alkoxytetrahydrofuran derivatives

1990-01-30

1990-12-25

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546283, C07D40512, A61K 3144

Patent

active

049803620

ABSTRACT:
The present invention describes a process to obtain 4-substituted 2-alkoxytetrahydrofuran derivatives of formula I, ##STR1## wherein, --R.sub.1 represents an alkyl or phenylalkyl radical; --R.sub.2 is hydrogen, C.sub.1 -C.sub.4 -acryl or C.sub.1 -C.sub.4 -alkoxycarbonyl; --R.sub.3 is either an electron pair, in which case t means nothing and q is zero, or R.sub.3 is hydrogen or C.sub.1 -C.sub.4 alkyl, in which case t is (+) and q=1; A- is a pharmaceutically acceptable anion. These compounds are antagonists of PAF and, therefore, useful for the treatment of the diseases in which this substance is involved.

REFERENCES:
patent: 4675390 (1987-06-01), Bonjouklian et al.
patent: 4820718 (1989-04-01), Tomesch

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