Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-02-17
1998-04-07
Feisee, Lila
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 723, 435 792, 43524027, 5303877, 53038885, G01N 3353, G01N 33574, C12N 500, C07K 1600
Patent
active
057363382
ABSTRACT:
In certain human tumor cells, the gene encoding MDM2 protein is amplified and expression of MDM2 protein is elevated. Since human MDM2 protein binds to human p53, excess MDM2 protein apparently releases a cell from p53-regulated growth. Detection of elevated amounts of human MDM2 protein thus can be used to diagnose neoplastic disease in a human.
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Burrell Marilee
Hill David E.
Kinzler Kenneth W.
Vogelstein Bert
Ebert Ray F.
Feisee Lila
The Johns Hopkins University
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