Antifungal azole compounds

Details Antifungal azole compounds Antifungal azole compounds

1984-02-21

1986-11-25

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544132, 546210, 548266, 548269, 548341, C07D24908

Patent

active

046250360

ABSTRACT:
This invention relates to novel antifungal azole compound of the formula: ##STR1## wherein X and Y are CH or N, R.sup.1 is optionally substituted phenyl or phenylalkyl, 1-6C alkyl or 3-8C cycloalkyl, R.sup.2 and R.sup.3 are hydrogen or 1-6C alkyl, and R.sup.4 and R.sup.5 are hydrogen, NH.sub.2, 1-6C alkyl, alkoxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylamino or alkenyl wherein each alkyl, alkoxy or alkenyl part is of 1-6C, phenyl, phenyl-(1-6C)-alkyl, phenoxy-(1-6C)-alkyl or phenyl-(2-6C)-alkenyl in which the phenyl may be optionally substituted, or a heterocyclyl, (heterocyclyl)-(1-6C)-alkyl or (heterocyclyl)-(2-6C)-alkenyl in each of which the heterocyclyl ring may be optionally substituted, provided at least one of R.sup.2, R.sup.3, R.sup.4 and R.sup.5 is other than hydrogen, and the acid addition salts of those compounds which contain a basic nitrogen; together with processes for their manufacture; compositions containing them; and a method of combatting plant fungal diseases.

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patent: 4038404 (1977-07-01), Meiser et al.
patent: 4358458 (1982-11-01), Scharwachter et al.
patent: 4404216 (1983-09-01), Richardson
patent: 4416682 (1983-11-01), Worthington
patent: 4483863 (1984-11-01), Richardson et al.
patent: 4510148 (1985-04-01), Richardson et al.
patent: 4554286 (1985-11-01), Richardson et al.
patent: 4587239 (1986-05-01), Regel et al.
Biochemical Pharmacology, vol. 26, pp. 1039-1042, Pergamon Press, 1977.
"Mode of Action of Antifungal Agents", Symposium of the British Mycological Society, A. P. J. Trinci & J. F. Ryley, Manchester, Sep. 1983, (pp. 321-341).

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