Novel androstadiene-17-carboxylic acid esters

Details Novel androstadiene-17-carboxylic acid esters Novel androstadiene-17-carboxylic acid esters

1979-10-30

1981-08-25

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2603971, 26039745, 26023955R, C07J 300, A61K 3156

Patent

active

042859379

ABSTRACT:
The invention provides novel esters of androstadiene 17-carboxyclic acids of the formula ##STR1## wherein R' represents a hydroxyl group which is esterified with a carboxyclic acid having not more than 7 carbon atoms, R" represents a methyl group in the .alpha.- or .beta.-position or the methylene group, wherein R is H or Cl, each of X and Y represents a hydrogen, chlorine or fluorine atom, with the proviso that at least one of these substituents is one of these halogens, when R is Cl, and that Y is only Cl or F and X only Cl, when R is H and that the androstadiene-17-carboxylic acid ester group does not contain more than 11 carbon atoms.
The new esters have pronounced antiinflammatory action coupled with remarkably low systemic side effects on thymus, adrenals and body weight. They are especially suitable to be used in dermatology.

REFERENCES:
patent: 3636010 (1972-01-01), Anner et al.
patent: 3856828 (1974-12-01), Phillipps et al.
patent: 4093721 (1978-06-01), Phillipps et al.
"Steroid Drugs" by Applezweig, (1962), pp. 523 and 524.

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