Enzyme derivatives for use in the treatment of venous thrombosis

Details Enzyme derivatives for use in the treatment of venous thrombosis Enzyme derivatives for use in the treatment of venous thrombosis

1979-08-20

1981-08-25

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

2601125R, 260112R, 435184, 435217, 435216, A61K 3748, C07C10352, C07G 700, C12N 970, C12N 968, C12N 999

Patent

active

042859328

ABSTRACT:
A pharmaceutical composition which comprises a pharmaceutically acceptable carrier together with an in vivo fibrinolytic enzyme as defined herein wherein the catalytic site essential for fibrinolytic activity is blocked by a group which is removable by hydrolysis at a rate such that the pseudo-first order rate constant for hydrolysis is in the range 10.sup.-6 sec.sup.-1 to 10.sup.-3 sec.sup.-1 in isotonic aqueous media at pH 7.4 at 37.degree. C.; is useful in the treatment of venous thrombosis.

REFERENCES:
C. Malen, et al., Chem. Abstr. vol. 76, 1972, p. 85810f.
Z. Skrzydlewski, et al., Chem. Abstr. vol. 78, 1973, p. 699v.
A. J. Baillie, et al., Chem. Abstr. vol. 78, 1973, p. 53467z.
L. Nanninga, Chem. Abstr. vol. 82, 1975, p. 106973c.
T. Chase, Jr., et al., Biochemistry 8, 1969, pp. 2212-2224.

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