Cyclic analogues of callidine

Details Cyclic analogues of callidine Cyclic analogues of callidine

1979-09-26

1981-08-25

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

042858577

ABSTRACT:
Novel cyclic analogues of callidine have the following general formula: ##STR1## wherein Pro is moiety of L-proline, Gly--that of glycine, Phe--phenylalanine, Arg--L-argenine; R is a residue of .alpha.- or .omega.-aminoacid or peptide; R.sub.1 is a residue of .alpha.- or .omega.- amino-acid; R.sub.2 is L-serine or glycine, the carbonyl group of arginine being connected either with R or with R.sub.1 by means of a covalent peptide bond using the .omega.-amino group of the aminoacid located in the 1 or 2 position of the calladine sequence. The novel compounds according to the present invention possess a prolonged hypotensive effect of selective character.

REFERENCES:
patent: 3216992 (1965-11-01), Bodansky et al.
patent: 3247181 (1966-04-01), Schwyzer et al.
J. Meienhofer., Liebigs Ann. Chem. Bd. 691, (1965), pp. 218-225.

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