N-substituted lactams useful as cholecystokinin antagonists

Details N-substituted lactams useful as cholecystokinin antagonists N-substituted lactams useful as cholecystokinin antagonists

1990-12-11

1993-04-13

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514422, 514424, 548526, 548531, 548537, 548550, A61K 3140, C07D20712

Patent

active

052023443

ABSTRACT:
This invention relates to novel N-substituted lactams having the following formula ##STR1## useful in the treatment and prevention of Cholecystokinin (CCK) related disorders of the gastrointestinal, central nervous and appetite regulatory systems of mammals.

REFERENCES:
patent: 3474093 (1969-10-01), McCaully et al.
patent: 4200572 (1980-04-01), Gleason et al.
patent: 4260743 (1981-04-01), Bose
patent: 4757068 (1988-07-01), Parsons
C.A., 112:77940v; Garvey et al., vol. 112 (1987).
Garvey, et al., J. of Org. Chem., 1990, 55, pp. 936-940.
Chemical Abstract; 73(15):77105c, (1970); Bayer, et al.
J. A. Williams; Biomedical Research (1982) 3, pp. 107-121.
M. Albus; Prog. Neuro Psychopharmacol & Biol. Psychiat. (1988), 12, pp. S5-S21.
U. Scheurer et al., Am. J. Physicol. (1983) 244, pp. G266-G272.
E. Corazziari, et al., Dig. Dis. & Sci. (1990) 35, pp. 50-54.
Harvey & Read, The Lancet (1973) Sat. 6 Jan., pp. 7793-7795.
C. Niederau, et al., Gastroenterology (1985), 88, pp. 1192-1204.
P. L. Faris, et al., Science (1983), 219, pp. 310-312.
N. S. Baber, et al., Pain (1989), 39, pp. 307-328.
G. P. Smith, Eating and its Disorders (1984), pp. 67-75.
Trends in Pharmacol. Sci. (1990), 11, pp. 271-273, Ravard, et al.
J. N. Crawley, Cholecystokinin Antagonists, Wang & Schoenfeld, (1988) pp. 243-262.
S. A. Watson, Gut (1989) 30, A1447.
Douglas, et al., Cancer Research (1989), 49, pp. 2438-2441.

Affiliated with

Also associated with

Rating

N-substituted lactams useful as cholecystokinin antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-substituted lactams useful as cholecystokinin antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-substituted lactams useful as cholecystokinin antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1155679