Method and composition for treating atherosclerosis

Details Method and composition for treating atherosclerosis Method and composition for treating atherosclerosis

1982-08-13

1984-04-24

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424250, 424251, 424261, 424267, 424304, 424319, 424330, A61K 31475

Patent

active

044447787

ABSTRACT:
A method of improving the arteriosclerotic condition in an animal having arteriosclerosis or having a high risk of developing arteriosclerosis, which method comprises administering an effective amount of a serotonin regulating agent, to inhibit the biological activity of serotonin within the blood vessels, thereby inhibiting the proliferation of smooth muscle cells, which has been found to cause or contribute to an arteriosclerotic condition.

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Yamori, Y., et al., J. Pharm. Pharmac., 1972, 24 (9), 690-695.
Goodman and Gilman's The Pharmacological Basis of Therapeutics, 6th Ed., Macmillan, New York, 1980, pp. 202-203.
Ross, R., et al., New England J. Med., 295, 369-377 and 420-425 (1976).
Friedman, R., et al., Prog. Hemostasis and Thromb., 4, 249-278 (1978).
Coughlin, S., et al., Nature, 288, 600-602 (1980).
Goldberg, I., et al., Science, 205, 920-922 (1979).
Shimamoto, T., Acta Path. Jap. 19 (1), 15-43 (1969).

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