Substituted thiazolo[3,2-a]pyrimidines and process for their pre

Details Substituted thiazolo[3,2-a]pyrimidines and process for their pre Substituted thiazolo[3,2-a]pyrimidines and process for their pre

1982-07-14

1984-04-24

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544278, 544281, 544282, 548190, C07D51304, A61K31 505

Patent

active

044447736

ABSTRACT:
Pharmacologically active thiazolo[3,2-a]pyrimidines of the formula ##STR1## wherein A is a bond between the .alpha. and .beta.-carbon atoms or (--CH.sub.2 --) group; R.sub.1 and R.sub.2 represent hydrogen or halogen, C.sub.1 -C.sub.4 alkyl, cyano, CF.sub.3, thienyl, pyridyl, biphenyl, naphtyl, phenyl optionally substituted, ##STR2## wherein R' and R" are hydrogen or alkyl; R.sub.3 represents hydrogen, halogen, alkyl, OH, formyloxy, alkanoyloxy, alkenyloxy; R.sub.4 represents pyridyl optionally substituted by alkyl. The compounds have antiinflammatory, antiulcerogenic and anti-gastric secretory activity.

REFERENCES:
patent: 3594378 (1971-07-01), Laliberte
patent: 3888983 (1975-06-01), Baetz

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