Production of benzaldehyde compounds

Details Production of benzaldehyde compounds Production of benzaldehyde compounds

1999-04-12

2000-08-08

Davis, Zinna Northington

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546340, C07D41700

Patent

active

061004030

ABSTRACT:
A method of producing a compound represented by the formula: ##STR1## wherein R.sup.1 stands for hydrogen or an optionally substituted alkyl or acyl group, which comprises reacting a compound represented by the formula: ##STR2## wherein R.sup.1 is of the same meaning as defined above, and R.sup.2 stands for an optionally halolgenated alkyl group or an optionally substituted phenyl group with a compound represented by the formula: ##STR3## in a lower alcohol in the presence of an alkali metal or alkaline earth metal carbonate; the compound (III) being useful as starting compounds for producing thiazolidinedione derivatives having hypoglycemic and hypolipidemic activities.

REFERENCES:
Y. Momose et al. "Studies on Antidiabetic Agents. X..sup.1) Synthesis and Biological Activities of Pioglitazone and Related Compounds", Chem. Pharm. Bull., vol. 39, No. 6, pp. 1440-1445, 1991.

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