Tricycle substituted with azaheterocyclic carboxylic acids

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514329, 514408, 514431, 514437, 540 10, 540 12, 540 26, 540 27, 546203, 546204, 549488, 549495, A61K 3155, A61K 31445, C07J 2100, C07D21106, C07D30748

Patent

active

061002534

ABSTRACT:
The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.

REFERENCES:
patent: 5595989 (1997-01-01), Andersen et al.

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