Process for the manufacture of 2-alkoxy-6-bromo-naphthalenes

Details Process for the manufacture of 2-alkoxy-6-bromo-naphthalenes Process for the manufacture of 2-alkoxy-6-bromo-naphthalenes

1977-04-28

1979-01-30

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568737, 568634, 562467, C07C 4110

Patent

active

041372727

ABSTRACT:
A new process, which can be carried out on the technical scale, had been found for the preparation of 2-alkoxy-6-bromo-naphthalenes, especially suitable as starting compounds for the synthesis of estrogens, which comprises brominating 2-hydroxy-naphthalene-1-carboxylic acid with bromine, decarboxylating the 6-bromo-2-hydroxynaphthalene-1-carboxylic acid by heating the reaction mixture at 100 - 125.degree. C, and alkylating the 6-bromo-2-hydroxy-naphthalene formed. The process can be conducted easily and with high yields.

REFERENCES:
patent: 2488472 (1949-11-01), Kremers

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