Method for the production of maytansinoids

Details Method for the production of maytansinoids Method for the production of maytansinoids

1978-03-15

1979-01-30

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

42424854, 2602393T, C07D49818

Patent

active

041372301

ABSTRACT:
Maytansinoid compounds are produced by contacting in the presence of a carbodiimide the compound maytansinol ##STR1## with an acid of the formula: ##STR2## wherein R is lower alkyl, to yield the desired maytansinoids HAVING THE RESULTANT FORMULA: ##STR3## wherein R is lower alkyl. The maytansinoids (I) are both antifungal agents and also antitumor agents.

REFERENCES:
patent: 3896111 (1975-07-01), Kupchan
White, Diss. Abstr. Int. B, (1976), vol. 37, No. 6, pp. 2867-2868.
Corey et al., Tetrahedron Letters, (1975), pp. 2643-2646.
Wolpert- Defilippes, "Biochemical Pharmacology", vol. 24, pp. 251-254 (1975).
Hanka, "Antimicrobial Agents and Chemotherapy", pp. 651-652, vol. 6, No. 5, (1974).
Kupchan, "J. of Organic Chemistry", vol. 42, No. 14, pp. 2349-2357 (1977).
Brinkmeyer Diss. Abstr. Int. B, (1975), vol. 36, No. 4, p. 1704.
Kupchan, "J. Am. Chem. Soc.", vol. 94, No. 4, pp. 1354-1356 (1972).
Kupchan, "J. Chem. Soc. Chem. Comm.", (1972), p. 1065.
Kupchan, "J. Am. Chem. Soc.", vol. 96, No. 11, pp. 3706-3708 (1974).
Kupchan, "J. Am. Chem. Soc.", vol. 97, No. 18, pp. 5294-5295 (1975).
Doctoral Thesis of Raymond S. Brinkmeyer at Colorado State Univ., (1975).
Doctoral Dissertation of William Anderson White of Univ. of Maryland, (1976).

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