Spatially-localized chemical-reaction-rate NMR spectroscopic ima

Surgery – Truss – Pad

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324307, 324309, A61B 5055

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active

052013111

ABSTRACT:
A method for providing information about the rate of a selected chemical reaction in each of at least one selected volume elements (voxels) in a sample includes the steps of: exciting a reaction-rate-dependent chemical-shift spectrum, by a selected stimulus (such as one of saturation-transfer and inversion-transfer RF signal pulses) to label the NMR signal of a first reaction constituent; spatially localizing the NMR response signal, provided by the excited resonance, to a selected voxel within the sample; and acquiring and processing the NMR response data from the localized voxel. The excitation, localization and data acquisition subsequences are repeated to generate data substantially proportional, or equal, to the reaction rate constants in the selected voxels, and in planes and/or volumes thereof.

REFERENCES:
patent: 4777439 (1988-10-01), Granot
patent: 4794337 (1988-12-01), Twieg
patent: 4878021 (1989-10-01), Granot
patent: 4881032 (1989-11-01), Bottomley et al.
patent: 4945308 (1990-07-01), Doddrell et al.
"Nuclear Magnetic Resonance and Its Applications to Living Systems", D. G. Gadian, 1982, Oxford University Press, New York (1982), pp. 131-132.

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