Process for the preparation of optically active secondary arylam

Details Process for the preparation of optically active secondary arylam Process for the preparation of optically active secondary arylam

1987-07-29

1991-02-19

Hines, Robert V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

544159, 544299, 546329, 548490, 548557, 549 72, 549480, 564302, C07C 5700

Patent

active

049946153

ABSTRACT:
Asymmetric hydrogenation of prochiral N-arylketimines to give optically active secondary amines at a temperature of -20.degree. to 80.degree. C., a hydrogen pressure of 10.sup.5 to 6.10.sup.6 Pa with the addition of catalytic amounts of an iridium compound of the formula III or IIIa

REFERENCES:
patent: 2608583 (1952-08-01), Aschner
patent: 3849480 (1974-11-01), Knowles et al.
patent: 3883580 (1975-05-01), Solodar
patent: 3968147 (1976-07-01), Solodar
patent: 4187313 (1980-02-01), Gschwend et al.
patent: 4556740 (1985-12-01), Hansen et al.
H. B. Kagan, Chiral Ligands for Asymmetric Catalysis, Asymmetric Synthesis, vol. 5, pp. 13-23 (1985).
R. Uson et al, Inorg. Chem. Acta 73, p. 275 et seq. (1983).
S. Brunie et al., Journal of Organometallic Chemistry, 114 (1976), pp. 225-235.
M. Green et al., J. Chem. Soc. (A), pp. 2334 et seq. (1971).

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