Method for preparing 7-oxabicycloheptyl substituted heterocyclic

Details Method for preparing 7-oxabicycloheptyl substituted heterocyclic Method for preparing 7-oxabicycloheptyl substituted heterocyclic

1992-06-18

1993-11-09

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546275, 546269, 5483117, 548525, 549463, C07D26332

Patent

active

052604489

ABSTRACT:
A method is provided for preparing 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs which are thromboxane A.sub.2 (TXA.sub.2) receptor antagonists or combined thromboxane A.sub.2 receptor antagonists/thromboxane synthetase inhibitors useful, for example, in the treatment of thrombotic and/or vasospastic disease, wherein a vinyl bromide of the formula, for example, ##STR1## wherein m, n, R.sup.1 and R.sup.2 are as defined herein is treated with a cyclizing agent to form the corresponding oxazole.

REFERENCES:
patent: 5100889 (1992-03-01), Misra et al.
patent: 5158967 (1992-10-01), Hall
CA 114:164202r, Preparation of . . . vasorelaxants, Misra, p. 776, 1991.

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