Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the

Details Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the

1992-11-06

1993-11-09

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514825, A61K 31415

Patent

active

052603288

ABSTRACT:
Heteroaryl-3-oxo-propanenitrile derivatives of formula (I) ##STR1## wherein X represents an oxygen atom or a --CH(R.sub.4)--, --O--CH(R.sub.4)--, --S(O).sub.n --CH(R.sub.4)--, --CH(R.sub.4)--O--, --CH(R.sub.4)--S(O).sub.n -- or --CH(R.sub.4)--CH.sub.2 -- group wherein n is 0, 1 or 2; R.sub.1 represents C.sub.1 -C.sub.6 alkyl, pyridyl or unsubstituted or substituted phenyl; R.sub.2, R.sub.3, and R.sub.4 are as herein defined; and Q is hydrogen, carboxy, C.sub.2 -C.sub.7 -alkoxycarbonyl or a --CON(R.sub.a)R.sub.b group, R.sub.a and R.sub.b being as defined herein; and their pharmaceutically acceptable salts are useful in the preparation of pharmaceutical compositions active in the treatment of autoimmune diseases.

REFERENCES:
patent: 4173634 (1979-11-01), Kuapcho
patent: 4268516 (1981-05-01), Lombardino
patent: 4415569 (1983-11-01), Yasuo
Jurgen Drews, "Immunpharmakologie", 1986, Springer-Verlag, (Berlin DE), pp. 71-73.
The Merck Manual of Diagnosis and Therapy, 15th edition, 1987, Merck Sharp & Dohme Research Laboratories, (Rahway, NJ, US), pp 319-322.

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