Chromanes and their pharmaceutical compositions and methods

Details Chromanes and their pharmaceutical compositions and methods Chromanes and their pharmaceutical compositions and methods

1992-05-27

1993-11-09

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514337, 514456, 514444, 544105, 546269, 549 60, 549408, 549410, A61K 3135, C07D31160

Patent

active

052602940

ABSTRACT:
Racemic Compounds of the formula ##STR1## A is --C.tbd.C--R.sub.6, --CH.sub.2 --CH.sub.2 --R.sub.7 or ##STR2## and the remainder of the variables are as defined in the specification, and their enantiomers and salts thereof are described.
The compounds of formula I exhibit activity as inhibitors of 5-lipoxygenase and inhibit lipid peroxidation. They are, therefore, useful in the treatment of diseases caused or aggravated by excess oxidative metabolism of arachidonic acid via the 5-lipoxygenase pathway and in the treatment of inflammation, arthritis, allergies, asthma and psoriasis. The compounds of formula I can also be used to prevent peroxidation of lipids and thus protect lipid membranes from oxidative stress.

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CA 103:53956t, Koho, a-amino acid derivatives Jan. 7, 1985 p. 8.
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