Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1992-05-11
1993-11-09
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514102, 514108, 514 99, 514143, 514144, 514925, 514927, A61K 3166
Patent
active
052602877
ABSTRACT:
Compositions and methods for protecting the luminal lining against gastric acid challenge are disclosed. The compositions provide effective anti-ulcer preparations which include phosphorylated alcohol. Phosphorylated alcohols comprise the active anti-ulcerogenic ingredient of the described therapeutic formulations. The preparation of unique linear and cyclic polyphosphorylated alcohols and methods of using same to protect the stomach luminal lining against acid challenge are also disclosed. Inositol hexaphosphate and mannitol hexaphosphate are demonstrated to provide therapeutic value in the treatment and prevention of gastro-erosive disease precipitated by exposure of biological tissues to highly acidic substances, for example, the gastric digestive acids. While inositol hexaphosphate alone at subthreshold concentrations provides a small gastro-protective activity, a combination of inositol hexaphosphate (at subthreshold concentrations) with polyvalent cations, such as Au.sup.+3 or Bi.sup.+3, provides synergistic enhancement of the composition as a gastro-protective formulation.
REFERENCES:
patent: 4473563 (1984-09-01), Nicolau et al.
patent: 5023248 (1991-06-01), Siren
patent: 5082833 (1992-01-01), Shamsuddin
Barreto Jose C.
Lichtenberger Lenard M.
Board of Regents , The University of Texas System
Jarvis William
Waddell Frederick E.
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