Methods of reducing porphyrin toxicity using fatty acids

Details Methods of reducing porphyrin toxicity using fatty acids Methods of reducing porphyrin toxicity using fatty acids

1996-03-06

1996-12-31

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514427, 514886, 540145, A61K 3120, A61K 3140

Patent

active

055895093

ABSTRACT:
A composition comprises a polyunsaturated fatty acid, in particular an essential fatty acid of the n-6 series (linoleic acid or its metabolites) or the n-3 series (alpha-linolenic acid and its metabolites), together with a drug that taken alone has a side-effect of sensitizing the skin to light, in particular a porphyrin or tetracycline or Benoxaprofen, alone or in a pharmaceutically acceptable diluent or carrier, the composition reducing that sensitization.

REFERENCES:
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Reyftmann et al., Photochemistry and Photobiology vol. 40, No. 6, pp. 721-729, 1984.
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Merck Manval (Rahway, N.J. Merck and Co., 1987) pp. 158-159, and 2506-2507.
Martindale Extra Pharmacopoeia 28th Ed. Reynolds Ed. (London, The Pharmaceutical Press, 1982 pp. 247, and 694-699.
Greene, Protective Groups in Organic Synthesis (New York, J. Wiley and Sons, 1981) pp. 154 to 157.
Reyftmann, et al. Photochem and Photobiol. 40(6) 721-729, 1984.
Reyftmann et al. Chemical Abstracts, vol. 103, 1985, Abstract 50057.
Chemical Abstracts, vol. 106, No. 8 Feb. 1987, p. 374, Abstract No. 55898m U.S.; RO-A-89 028.
EPO Search Report.

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