Treatment of newborn jaundice

Details Treatment of newborn jaundice Treatment of newborn jaundice

1994-07-26

1996-12-31

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514562, 514578, 514706, 514731, 514739, 514764, A61K 3136, A61K 31195, A61K 31185, A61K 31095

Patent

active

055895042

ABSTRACT:
Based on the discovery that the human bilirubin/phenol UDP-glucuronosyltransferase ugt1 gene complex contains an electrophile responsive element and the knowledge that the rat NADP(H):quinone reductase gene contains an electrophile responsive element, agents which at a concentration of less than 50 .mu.M double the quinone reductase specific activity of Hepa 1clc7 cells, e.g., BHT and sulforaphane, are used for the prophylaxis or treatment of newborn jaundice.

REFERENCES:
patent: 4670285 (1987-06-01), Clandinin et al.
patent: 4753926 (1988-06-01), Lucas et al.
patent: 5234702 (1993-08-01), Katz et al.
Hankinson, O., Proc. Natl. Acad. Sci. USA 76, No. 1, 373-376, Jan. 1979.
Hankinson, O., Biochimie 73, 61-66 (1991).
Stern, L., et al, Am. J. Dis. Child, vol. 120, 26-31, Jul. 1970.
Sutherland, L., et al, Chemical Pharmacology, vol. 45, No. 2, 295-301, 1993.
Zhang, Y., et al, Proc. Natl. Acad. Sci. USA, vol. 89, 2399-2403, Mar. 1992.
Zhang, Y., et al, Proc. Natl. Acad. Sci. USA, vol. 91, 3147-3150, Apr. 1994.
Sutherland, L., et al, Biochemical Pharmacology, vol. 45, No. 2, 295-301, 1993.
Dannenberg A. J., et al, Programme and Abstracts, 7th International Workshop on Glucuronidation and the UDP-glucuronosyltransferases, p. 19, Sep. 1993.
Bosma, P. J., et al, Hepatology, vol. 18, No. 4, Pt 2, AASLD Abstracts, p. 127A, abstract 1283, 1993.
Cha, Y-N., et al, Cancer Research 42, 2609-2615, Jul. 1982.
Prestera, T., et al, Advan. Enzyme Regul., vol. 33, 281-296, 1993.
Prestera, T., et al, Proc. Natl. Acad. Sci USA, 90, 2965-2969 (Apr. 1993).
Talalay, P., "The Role of Enzyme Induction in Protection Against Carcinogenesis", In: Cancer Chemoprevention, L. Wassenberg et al, eds., CRC Press, Boca Raton, Fla., 469-478, 1992.
Dannenberg, A. J., et al, "Dietary Regulation of UDP-Glucuronosyltransferase, Glucuronidation Workshop", Scotland, Sep. 1993.
Prochaska, H. J., et al, Anal. Biochem. 169, 328-336 (1988).
Prochaska, H. J., et al, Proc. Natl. Acad. Sci. USA, 89, 2394-2398, Mar. 1992.
Yang, E. K., "Effect of Dietary Composition on Bilirubin-UDP-glucuronosyltransferase," presented Nov. 1993 in Chicago at meeting of American Association for Study of Liver Diseases.
Bergelson, S., et al, Oncogene 9: 565-571, 1994.
Bock, K. W., et al, Xenobiotica, 20, 1101-1111, 1990.
Owens, I. S., et al, Pharmacogenetics, 2, 93-108 (1992).
Posner, G. H., et al, J. Med. Chem. 37, 170-176 (1994).
Talalay, P., et al, Proc. Natl. Acad. Sci. USA, vol. 85, 8261-8265, Nov. 1988.
DeLong, M. J., et al, Proc. Natl. Acad. Sci. USA, vol. 83, 787-791, Feb. 1986.
DeLong, M. J., et al, Cancer Research 45, 546-551, Feb. 1985.
Rushmore, T. H., et al, The Journal of Biological Chemistry, vol. 266, No. 18, 11632-11639 (Jun. 1991).
Spencer, S. R., et al, Cancer Research 50, 7871-7875 (Dec. 1990).
Yang, E. K., et al, Hepatology, vol. 18, No. 4, Pt. 2, AASLD Abstracts, p. 127A, Abstract 282 (1993).
Yeung, C. Y., et al, Pediatrics, vol. 48, No. 3, 372-376 (Sep. 1971).

Affiliated with

Also associated with

Rating

Treatment of newborn jaundice does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Treatment of newborn jaundice, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment of newborn jaundice will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1142490