Process for preparing amide n-carbox-amides

Details Process for preparing amide n-carbox-amides Process for preparing amide n-carbox-amides

1995-04-18

1995-11-21

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548431, 548450, 564 45, 564 46, C07D20930

Patent

active

054688736

ABSTRACT:
The present invention provides a process for preparing 2-oxindole-1-carboxamides, comprising reacting N-acyl 2-oxindole-1-carboxamides with alcohols in the presence of aprotic weak Lewis acid catalysts. In certain processes of the present invention a 2-oxindole-1-carboxamide is prepared from a 2-oxindole by reacting the 2-oxindole with an acyl isocyanate to produce the N-acyl 2-oxindole-1-carboxamide as an intermediate, which is then reacted with alcohol in the presence of aprotic weak Lewis acid catalysts The N-acyl 2-oxindole-1-carboxamide intermediate may be converted to the 2-oxindole-1-carboxamide without isolation.

REFERENCES:
CA114-184822w Preparation of N-(.alpha.-alkoxyethyl)carboxamides. Sugita et al., p. 724, 1991.

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