Rebeccamycin analogs by tryptophan analogs feeding

Details Rebeccamycin analogs by tryptophan analogs feeding Rebeccamycin analogs by tryptophan analogs feeding

1994-03-21

1995-11-21

Fox, David T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 187, 536 168, 536 169, 536 221, 435 85, 435 87, C07G 300, C07H 1100, C07H 1702, C12P 1928

Patent

active

054688493

ABSTRACT:
Addition of certain tryptophan analogs to the culture medium during fermentation of a rebeccamycin-producing strain of Saccharothrix aerocolonigenes results in production of new rebeccamycin analogs having advantageous antitumor properties.

REFERENCES:
patent: 4487925 (1984-12-01), Nettleton et al.
patent: 4552842 (1985-11-01), Nettleton et al.
patent: 4785085 (1988-11-01), Kaneko et al.
patent: 4808613 (1989-02-01), Kaneko et al.
Pazoutova, S., et al., "The Inhibition of Clavine Biosynthesis by 5-Fluorotryptophan; a Useful Tool for the Study of Regulatory and Biosynthetic Relationships in Claviceps," Applied Microbiology and Biotechnology, 33:330-334 (1990).
Adams, E. S., et al., "Directed Biosynthesis of 5"-Fluoropactamycin in Streptomyces pactum," The Journal of Antibiotics, 47:(12), pp. 1456-1465 (1994).
Cannell, R. J. P., et al., "Production of Additional Squalestatin Analogues by Directed Biosynthesis," The Journal of Antibiotics, 47:(2), pp. 247-249 (1994).
Cannell, R. J. P., et al., "The Squalestatins, Novel Inhibitors of Squalene Synthase Produced by a Species of Phoma," The Journal of Antibiotics, 46:(9), pp. 1381-1389 (1993).
Chen, T. S., et al., "The Preparation of Zaragozic Acid A Analogues by Directed Biosynthesis," The Journal of Antibiotics, 47:(11), pp. 1290-1294 (1994).
Becker, A. M., et al., "3-Amino-5-Hydroxybenzoic Acid in Antibiotic Biosynthesis VI. Directed Biosynthesis Studies with Ansamycin Antibiotics", The Journal of Antibiotics, 36:(10), pp. 1323-1327 (1983).
Lam, K. S., et al., "Isolation of a Bromo Analog of Rebeccamycin From Saccharothrix aerocolonigenes," The Journal of Antibiotics, 44:(9), pp. 934-939 (1991).
"Isosterism and Molecular Modification in Drug Design," Chemical Society Reviews, vol. 8, pp. 563-579 (1979).
Houck, D. R., et al., "On the Biosynthesis of Asperlicin and the Directed Biosynthesis of Analogs in Aspergillus Alliaceus," The Journal of Antibiotics, 41:(7), pp. 882-891 (1988).
Bush, J. A. et. al., J. Antibiotics, 40:668-678 (1987).

Affiliated with

Also associated with

Rating

Rebeccamycin analogs by tryptophan analogs feeding does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Rebeccamycin analogs by tryptophan analogs feeding, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Rebeccamycin analogs by tryptophan analogs feeding will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1138270