Aralkyl-N-hydroxyureas as inhibitors of 5-lipoxygenase and oxida

Details Aralkyl-N-hydroxyureas as inhibitors of 5-lipoxygenase and oxida Aralkyl-N-hydroxyureas as inhibitors of 5-lipoxygenase and oxida

1993-11-08

1995-11-21

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548236, A61K 3142

Patent

active

054687608

ABSTRACT:
This invention relates to compounds compounds useful in treating diseases mediated by one or more leukotrienes or oxidative modification of low density lipoprotein such as inflammation, bronchoconstriction or atherosclerosis. The compounds of this invention have the formula: ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, fluorine, chlorine, bromine, iodine, C.sub.1 -C.sub.6 alkyl, trifluoromethyl, C.sub.1 -C.sub.6 alkoxy, or C.sub.1 -C.sub.6 trifluoroalkoxy; R.sup.2 and R.sup.4 are hydrogen or methyl independently;

REFERENCES:
patent: 4895953 (1990-01-01), Musser et al.
patent: 5185363 (1993-02-01), Brooks et al.
patent: 5334604 (1994-08-01), Goldstein et al.
Reaven et al., Arteriosclerosis and Thrombosis 12(3), 318-21 (1992).
Steinberg, Amer J of Cardiology 57, 16H-21H, (1986).
Carew, Schwenke and Steinberg, Proc. Natl. Acad. Sci. 84, 7725-29 (1987).
Nagano et al., Arteriosclerosis 9(4), 453-461 (1989).

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