Phenylalanine-glycine compounds having anti-tumor activity, proc

Details Phenylalanine-glycine compounds having anti-tumor activity, proc Phenylalanine-glycine compounds having anti-tumor activity, proc

1993-03-15

1995-05-02

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514274, 514533, 514534, 514538, 514539, 514542, 514563, 544311, 544312, 544313, 560 21, 560 22, 560 29, 560 32, 562445, 562448, A61K 31505, A61K 31215, C07D23912, C07C22928

Patent

active

054119642

ABSTRACT:
A phenylalanine-glycine compound of formula (I): ##STR1## wherein R represents a residue of an antitumor substance, or a salt or ester thereof, a process for preparation thereof, and a pharmaceutical composition containing the same are described. The novel conjugate of the phenylalanine-glycine compound and the antitumor substance exhibits superior antitumor activity in comparison with the case wherein an antitumor substance is administered alone or as a mixture with phenylalanine.

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