Use of TGF-.beta..sub.3 to reduce the formation of scar tissue i

Details Use of TGF-.beta..sub.3 to reduce the formation of scar tissue i Use of TGF-.beta..sub.3 to reduce the formation of scar tissue i

1993-09-29

1995-05-02

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, A61K 3702, A61K 3736

Patent

active

054119405

ABSTRACT:
The use of TGF-.beta..sub.3 to reduce the formation of scar tissue as a result of trauma to the cornea of the eye is described. The invention is particularly directed to the use of TGF-.beta..sub.3 to reduce the formation of scar tissue in connection with ophthalmic surgical procedures involving the cornea, such as laser irradiation of the cornea. A composition containing TGF-.beta..sub.3 is applied to the site of the trauma to alter the production and composition of extracellular matrix synthesized by fibroblasts, and thereby reduce the formation of scar tissue and consequent impairment of vision.

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