Benzimidazole compounds

Details Benzimidazole compounds Benzimidazole compounds

1992-06-24

1994-01-18

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 93, 546 94, C07D45100, C07D47100, A61K 3141, A61K 31435

Patent

active

052800288

ABSTRACT:
This invention relates to compounds useful in treating HT.sub.4 and/or HT.sub.3 mediated conditions of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, alkoxy, halogen, amino, monoalkylamino, dialkylamino, acylamino and alkylsulfonylamino; R.sub.3 is selected from the group consisting of H, alkyl and cycloalkyl; X is NH or O; Z is selected from the group consisting of ##STR2## n and r are independently 1 or 2; p is 0 or 1; pharmaceutical compositions containing the compounds and a method for treating serotonin mediated condition with the compositions which act as 5-HT.sub.4 agonists or antagonists and/or 5-HT.sub.3 antagonists.

REFERENCES:
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patent: 5137893 (1992-08-01), Becker et al.
patent: 5140023 (1992-08-01), Becker et al.
Schiantarelli et al. Pharmacological Research 22, Supp. 2 453 Jan. 1990.
A. Dumuis et al. Azabicycloalkylbenzimidazolone derivatives as etc. Naunyn-Schmiedeberg;s Arch Pharmacol 343 245-251 Jan. 1991.
M. Turconi et al. Synthesis of a New Class of etc. J. Med. Chem. 33, No. 8 2101-2108 Jan. 1990.

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