Drug and method for increasing the microcirculatory flow-rate an

Details Drug and method for increasing the microcirculatory flow-rate an Drug and method for increasing the microcirculatory flow-rate an

1989-06-21

1994-01-18

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514103, 514121, 514119, 514114, 514428, 548413, A61K 31685, A61K 3140, A61K 3166

Patent

active

052800202

ABSTRACT:
A drug is described which includes a physico-chemical complex between molecules of a phospholipid and an aminoketone derivative of fluoroglucinol which is useful, particularly when administered topically in the form of a liposomal aqueous microdispersion, for increasing the microcirculatory flow-rate and volume in the capillaries to the skin, both in normal conditions and in peripheral vasculopathy (primary or secondary Raynaud's disease), acrocyanosis and blocked arteries caused by arteriosclerosis, diabetes or endoangioitis obliterans.

REFERENCES:
patent: 3895030 (1975-07-01), Lafon
patent: 4742051 (1988-05-01), Muirhead et al.
The Merck Index, 10th ed. (Merck & Co., Inc.) (Rahway, N.J.) pp. 779-780 (1983).
A. Colantuoni et al., Changes in Arteriolar Vasomotion of Syrian hamster Skeletal Muscle Microcirculation, Italy, 1989.
A. Colantuoni et al., Quantitation of Rhythmic Diameter Changes in Arterial Microcirculation, 1984, American Physiological Society.
"Phospholipids, Chemistry, Metapolism and Function" by Answell et al., Elsevier Publishing Company, 1951, pp. 26-28.

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