Chemistry: analytical and immunological testing – Including chromatography
Patent
1993-08-10
1995-11-21
Housel, James C.
Chemistry: analytical and immunological testing
Including chromatography
73 6155, 2101982, 210656, 422 70, 422101, 436177, G01N 3002
Patent
active
054686431
ABSTRACT:
A valving arrangement and a method are provided by which a biological sample is mixed with a reactant, such as a solvent or a precipitating agent, as it is injected through a multi-position injection valve. A multi-position switching valve is connected to the injection valve, and one or more filters attached to the switching valve remove precipitates of predetermined size from the reacted sample. The sample the flows to conventional analytical columns for liquid chromatography analysis of analytes of interest. Proteins and/or peptides are thus quickly and efficiently removed from the sample as precipitates collected in the filters. The injection valve and the switching valve are then placed in respective cooperating positions to flow a carrier fluid through the injection valve and the switching valve directly to the analysis columns, while a back-flow of a suitable surfactant is pumped through the filters to purge them of collected precipitates. This quickly purges the system and puts it in condition for a repeat of the procedure. The apparatus and method may be used both when samples are provided manually under the direct control of an operator and when an autoinjector or autosampler of known type is employed for repeated sampling.
REFERENCES:
patent: 3030798 (1962-04-01), Lichtenfels
patent: 3087112 (1963-04-01), Pfefferle
patent: 3097519 (1963-07-01), Favre
patent: 3206968 (1965-09-01), Leggoe et al.
patent: 3285701 (1966-11-01), Robertson
patent: 3394582 (1968-07-01), Munro et al.
patent: 3457787 (1969-07-01), Maatsch et al.
patent: 3918913 (1975-11-01), Stevenson et al.
patent: 3923460 (1975-12-01), Parrott et al.
patent: 4057997 (1977-11-01), Chandler
patent: 4173145 (1979-11-01), Durbin
patent: 4229971 (1980-08-01), Ririe, Jr.
patent: 4359323 (1982-11-01), Le Page
patent: 4446105 (1984-05-01), Dinsmore et al.
patent: 4454043 (1984-06-01), Ting et al.
patent: 4526754 (1985-07-01), Burns et al.
patent: 4577492 (1986-03-01), Holba et al.
patent: 4751185 (1988-06-01), Ono et al.
patent: 4837157 (1989-06-01), Turnell et al.
patent: 4913821 (1990-04-01), Melcher et al.
patent: 4952514 (1990-08-01), Haddad
patent: 4980130 (1990-12-01), Metzger et al.
patent: 5057437 (1991-10-01), Binder
patent: 5061638 (1991-10-01), Guter
patent: 5075080 (1991-12-01), Sanders
Perry and Chilton, Chemical Engineer's Handbook, McGraw Hill, New York 1973 pp. 19-57 to 19-81.
Fisher Scientific Catalog 1988 pp. 402-403.
"A New Chromatograph for Pharmacokinetic Drug Monitoring by Direct Injection of Body Fluids", Journal of Chromatography, 222 (1981), pp. 13-22.
94:41093s, Chemical Abstracts, vol. 94, 1981, p. 8.
Single sheet illustrating commercially available embodiments of "Rheodyne Sample Injection Valve".
Single sheet illustrating High Pressure Components, Thomson Instrument Company.
Shiu Gerald K.
Su Syang Y.
Housel James C.
Ludlow Jan M.
The United States of America as represented by the Department of
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