Process for preparing 1-6-and 2-substituted-1-carba-2-penem-3-ca

Details Process for preparing 1-6-and 2-substituted-1-carba-2-penem-3-ca Process for preparing 1-6-and 2-substituted-1-carba-2-penem-3-ca

1982-07-15

1984-08-14

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424274, 424270, C07D48704, A61K 3140

Patent

active

044656327

ABSTRACT:
Disclosed are 1-, 6- and 2-substituted-1-carba-2-penem-3-carboxylic acids of the following structure: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, aryl, and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

REFERENCES:
patent: 4153714 (1979-05-01), Ponsford
patent: 4210661 (1980-07-01), Ponsford et al.

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