7-Cyanoalkylureido 3 heterocylic thio methyl cephalosporins

Details 7-Cyanoalkylureido 3 heterocylic thio methyl cephalosporins 7-Cyanoalkylureido 3 heterocylic thio methyl cephalosporins

1977-02-02

1978-06-20

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

260465D, 2604654, 260465E, 2604655R, 424 24L, 544 26, 544 27, 544 30, 544 24, 544 25, C07D50136

Patent

active

040963292

ABSTRACT:
Cyanoalkylureido cephalosporins of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen or methoxy; A is straight or branched chain alkylene or ##STR3## R.sub.2 is phenyl, 2-thienyl, or 3-thienyl; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl, substituted phenyl-lower alkyl, or certain heterocyclic groups; R.sub.5 is hydrogen or lower alkyl; R.sub.6 is lower alkyl; and X is hydrogen, lower alkanoyloxy, ##STR4## or certain heterothio groups; are disclosed. These compounds are useful as antibacterial agents.

REFERENCES:
patent: 3996217 (1976-12-01), Breuer et al.
patent: 3997533 (1976-12-01), Kabbe et al.

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