Process for preparing quinazolinone derivatives and their 2-(N-m

Details Process for preparing quinazolinone derivatives and their 2-(N-m Process for preparing quinazolinone derivatives and their 2-(N-m

1975-07-01

1978-06-20

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

2603265J, 2603323R, 2603477, 260570R, 260570AB, 544119, 544286, C07D23982, C07C 9710

Patent

active

040961443

ABSTRACT:
1,4-Substituted-2(1H)-quinazolinone derivatives are prepared by contactng a 2-aminophenyl ketone derivative with an alkaline agent such as alkali metal, alkali metal hydride, alkali metal amide, etc., reacting the thus obtained metal salt of 2-aminophenyl ketone derivative with a reactive ester of alcohols, reacting the thus obtained 2-(N-mono-substituted amino)-phenyl ketone derivative with a lower alkyl haloformate or a benzyl haloformate, and reacting the thus obtained carbamate derivative with ammonia. The 1,4-substituted-2(1H)-quinazolinone derivatives have excellent pharmacological properties, particularly as anti-inflammatory and analgesic effects.

REFERENCES:
patent: 2809994 (1957-10-01), Hinckley
patent: 3109843 (1963-11-01), Reeder et al.
Ott et al., "Chemical Abstracts," vol. 71, p. 302, 30502y (1969).

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