Substituted N-methylene derivatives of thienamycin

Details Substituted N-methylene derivatives of thienamycin Substituted N-methylene derivatives of thienamycin

1977-11-17

1980-03-18

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

2602452T, 2602452R, 26032614R, 26037625, 26037631, 424250, 424263, 424267R, 424270, 424272, 424273, 424274, 542416, 544144, 544238, 544282, 544373, 546 22, 546200, 546256, 548336, C07D48704, A61K 3140

Patent

active

041940474

ABSTRACT:
Disclosed are substituted N-methylene derivatives of thienamycin which may be represented by the following structural formula: ##STR1## wherein X and Y are selected from the group consisting of hydrogen, R, OR, SR, and NR.sup.1 R.sup.2 wherein, inter alia, R is substituted or unsubstituted: alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, and heterocyclylalkyl; R.sup.1 and R.sup.2 are hydrogen or R. Such compounds and their pharmaceutically acceptable salt, ether, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

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