Cephalosporin compounds

Details Cephalosporin compounds Cephalosporin compounds

1982-07-19

1986-01-07

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

514203, 544 25, C07D50118, A61K 31545

Patent

active

045635234

ABSTRACT:
The invention relates to the novel compound (6R,7R)-7-(D-5-benzamido-5-carboxypentanamido)-3-(1-pyridiniummethyl)-ceph -3-em-4-carboxylate and salts thereof, which may be prepared in substantially pure form. The novel compounds are useful for the preparation of (6R,7R)-7-amino-3-(1-pyridiniummethyl)ceph-3-em-4-carboxylate or salts thereof, which are themselves useful for the preparation of 7-substituted 3-pyridiniummethyl cephalosporin antibiotics such as ceftazidime and cephaloridine.

REFERENCES:
patent: 3261832 (1966-07-01), Cowley et al.
patent: 3449338 (1969-06-01), Flynn
patent: 3882103 (1975-05-01), Chapman et al.
patent: 4021426 (1977-05-01), Oppici et al.
patent: 4245088 (1981-01-01), Tsushima et al.
patent: 4369313 (1983-01-01), Jones et al.

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