Process for chiral enrichment of optically active carboxylic aci

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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560 56, C07B 5500

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active

059361182

ABSTRACT:
A highly efficient method for enriching the chiral purity of a partially enriched mixture of enantiomers of an optically active compound, a major portion of the partially enriched mixture of enantiomers comprising a first enantiomer of the optically active compound, a minor portion of the partially enriched mixture of enantiomers comprising a second enantiomer of the optically active compound. The method comprises mixing an acid in whatever form it may exist in solution with an aqueous solution of the partially enriched mixture of enantiomers, in whatever form the partially enriched mixture of enantiomers may exist in solution, to form a reaction mass comprising a further enriched mixture of enantiomers of the optically active compound, the further enriched mixture of enantiomers having a higher percentage of the first enantiomer than the partially enriched mixture. The optically active compound has the formula:

REFERENCES:
patent: 4246164 (1981-01-01), Felder et al.
patent: 4621152 (1986-11-01), Bernini
patent: 4625054 (1986-11-01), Bernini
patent: 5621140 (1997-04-01), Schloemer et al.

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