Tissue factor mutants useful for the treatment of myocardial inf

Details Tissue factor mutants useful for the treatment of myocardial inf Tissue factor mutants useful for the treatment of myocardial inf

1991-06-13

1994-09-13

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530381, 530829, 4351723, C07K 1300, C12N 1512, A61K 3702

Patent

active

053469917

ABSTRACT:
A tissue factor protein mutant capable of neutralizing the ability of endogenous tissue factor to induce coagulation is provided. A representative tissue factor mutant designated K165A, K166A TF is useful in a method for inhibiting thrombin-induced platelet aggregation in a mammal, either separately or in combination with a thrombolytic agent, an anticoagulant, or a GPII.sub.b III.sub.a inhibitor.

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O'Brien, D. P. et al. "Factor VIII-Bypassing Activity of Bovine Tissue Factor Using the Canine Hemophilic Model." J. Clin. Invest. 82:206-211 (1988).
Krangel, M. S. et al. "Characterization of a B Lymphoblastoid Cell Line, Mutant that Secretes HLA-AZ". J. of Immunol. 132(6):2984-2991 (1984).
Spicer, E. K. et al. "Isolation of cDNA clones coding for human tissue factor: primary structure and cDNA", PNAS, 84:5148-5152 (1987).

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