N-linked ureas and carbamates of heterocyclic thioesters

Details N-linked ureas and carbamates of heterocyclic thioesters N-linked ureas and carbamates of heterocyclic thioesters

1996-12-31

1999-08-10

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548533, A61K 3140, C07D20706

Patent

active

059359897

ABSTRACT:
This invention relates to neurotrophic low molecular weight, small molecule N-linked ureas and carbamates of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.

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