Phenoxyacetic acid derivatives

Details Phenoxyacetic acid derivatives Phenoxyacetic acid derivatives

1997-09-08

1999-08-10

Davis, Zinna Northington

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514372, 514364, 514529, 514546, 514617, 548131, 548214, 5483355, 5483415, 560 55, 562465, 564161, A61K 31425, A61K 31415, A61K 3141, A61K 3119

Patent

active

059359854

ABSTRACT:
We proposed a novel compound having an activity of PGI.sub.2 receptor agonist.
A phenoxyacetic acid derivative of the formula ##STR1## A is --C(R.sup.1).dbd.N.about.OR.sup.2, --CH(R)NH--OR.sup.2, --COE, --SO.sub.2 E, --CH.sub.2 --NR.sup.3 --Y, --Z--NR.sup.3 --CONR.sup.4 R.sup.5, --CH.sub.2 --OR.sup.6, --CO.sub.2 R.sup.6, --CH.sub.2 --O.about.N.dbd.CR.sup.7 R.sup.8, --CH.sub.2 --O--NHCHR.sup.7 R.sup.8, substituted by imidazolyl(methyl), pyrazolylmethyl, oxazolyl(methyl), thioxazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolylmethyl;

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