Aqueous suspension preparation for injection, method for produci

Details Aqueous suspension preparation for injection, method for produci Aqueous suspension preparation for injection, method for produci

1992-11-20

1994-09-13

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514567, 514975, 424400, A61K 31485

Patent

active

053469038

ABSTRACT:
The present invention relates to an aqueous suspension preparation for injection and to a method for producing the same and further relates to the use of said preparation for producing pain relief. The invention particularly relates to a preparation as indicated hereinabove, comprising a water-insoluble local anesthetic and/or narcotic analgesic suspended in an aqeuous medium, which preparation can be succesfully used for epidural and intrathecal pain relief and for conduction anesthesia and infiltration anesthesia. The preparation is stabilized by the addition of a non-ionic surface-active agent in an amount of less than 1 wt. %. The particles of the water-insoluble active agent have a mean particle diameter of less than 20 .mu.m. More than 99% of the particles have a diameter of less than 100 .mu.m and more than 90% have a diameter of less than 50 .mu.m.

REFERENCES:
patent: 4599354 (1986-07-01), Shulman
patent: 4963367 (1990-10-01), Ecanow
Gafitanu et al., Chemical Abstracts, CA100(10:73840s, 1982.
Korsten et al., Anesthesiology, 75: 950-960 (1991).

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