Aminomethanobenzazocines and nitromethanobenzazocines

Details Aminomethanobenzazocines and nitromethanobenzazocines Aminomethanobenzazocines and nitromethanobenzazocines

1978-01-16

1980-05-27

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424267, C07D22126

Patent

active

042051711

ABSTRACT:
3-Alkylated-8-aminated-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines, useful as strong analgesics, are prepared by one route comprising reduction of 8-nitro intermediates or by another route comprising Birch type reduction of 8-methoxy intermediates followed by dehydration-rearrangement of the oximes of the resulting 8-oxo intermediates.

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patent: 3966747 (1976-06-01), Monkovic et al.
Jacobson, A. et al., J. Med. Chem., 8, 563-566 (1965).

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