Treatment of lyso PAF-mediated diseases with PAF antagonists and

Details Treatment of lyso PAF-mediated diseases with PAF antagonists and Treatment of lyso PAF-mediated diseases with PAF antagonists and

1992-10-28

1994-09-13

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142312, 514282, A61K 3155, A61K 31535, A61K 3144

Patent

active

053468945

ABSTRACT:
The invention refers to the treatment of lyso-paf-mediated diseases with paf antagonists and a procedure for determining their efficacy. According to the invention for treating a disease caused by lyso paf (1-O-alkyl-sn-glyceryl-3-phosphocholine) as the precursor and metabolit of paf is found in elevated amounts in the liquor of mental and/or inflammatory diseases. Lyso paf regulates via its own receptor the paf receptors on human neutrophils which are then inhibited by paf antagonists. According to the invention for treating a mental and/or inflammatory diseases caused by lyso paf an effective amount of at least one paf antagonist is administered to a subject requiring said treatment, wherein the paf antagonist is a hydrophilic or non-hydrophilic triazolothieno-diazepine or a homologue thereof, a ginkgolide, a ginkgolide mixture or a synthetic ginkgolide derivate, or an analogue of the paf or a mixture with/of these compounds.

REFERENCES:
patent: 4571407 (1986-02-01), Chatterjee et al.
patent: 4734280 (1988-03-01), Braquet
Br. J. Pharmacol., "Interaction of the Paf antagonist WEB 2086 and its hetrazepine analogues with human platelets and endothelial cells", 1989, 98 pp. 653-661.
European Journal of Pharmacology, "Comparison of three paf-acether receptor antagonist ginkgolides", 152 1988, pp. 101-110.

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