Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-11-21
1986-01-07
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549 57, 514253, 549 60, 549355, 514309, 549408, 549462, 514310, 549510, 549511, 514312, 514313, 514361, 514362, 514363, 514367, 514369, 514370, 514382, 514383, 514414, 514422, 514443, 514444, 514469, 544405, 546143, 546160, 546269, 548126, 548128, 548151, 548159, 548193, 548256, 548266, 548454, 548525, 549 52, A61K 3134, A61K 3135, C07D31104, C07D30779
Patent
active
045634769
ABSTRACT:
Substituted 5-hydroxy-2,3-dihydrobenzofuran and analogs such as the substituted 6-hydroxy-2,3-dihydrobenzopyrans were prepared from an appropriately substituted (5-hydroxy-2,3-dihydrobenzofuran-6-yl) formaldehyde or analog thereof with an aryl amine followed by reduction. These compounds were found to be potent topical anti-inflammatory agents.
REFERENCES:
Wagner et al., Synthetic Org. Chem., (1953) Wiley & Sons, pp. 660-661.
Aldrich Catalog-Handbook of Org. and Biochemicals, 1975-1976 Ed., Publ. by Aldrich Chem. Co., pp. 738-740.
Handbook of Chem. and Physics, Chem. Rubber Co., 47th Ed. (1966) pp. C-116 through C-121.
Chang Michael N.
Hammond Milton L.
Jensen Norman P.
Zambias Robert A.
Cheng Theresa Y.
Dentz Bernard I.
Merck & Co. , Inc.
Monaco Mario A.
Schwartz Richard A.
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