Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-03-25
1999-08-10
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514304, 514315, 514323, 546125, 546126, 546132, 424 181, 424405, A61K 31535, A61K 3144, A01N 4342, C07D45102
Patent
active
059359536
ABSTRACT:
The invention relates to a method of controlling an invertebrate pest, comprising contacting the pest with a pest-controlling amount of an agent having substantial inhibitory activity toward a phenylethanolamine reuptake transporter as determined by radioactive octopamine reuptake inhibition assay is disclosed. Compositions comprising compounds capable of inhibiting the octopamine reuptake transporter include cocaine analogs. A process for inhibiting the feeding of an invertebrate pest comprising contacting said pest with a pest-controlling amount of an agent having substantial inhibitory activity toward a phenylethanolamine reuptake transporter as determined by radioactive octopamine reuptake inhibition assay, with the proviso that said agent is not cocaine. A process for delaying the maturation of a juvenile invertebrate by contacting it with an inhibitory amount of a phenylethanolamine reuptake transporter blocker is also disclosed. A radioactive phenylethanolamine reuptake inhibition assay for determining whether a given compound is an inhibitor of octopamine neuronal transport is also disclosed.
REFERENCES:
patent: 3813404 (1974-05-01), Clark et al.
patent: 5128118 (1992-07-01), Kuhar et al.
patent: 5366975 (1994-11-01), Nathanson
patent: 5374636 (1994-12-01), Moldt et al.
patent: 5380848 (1995-01-01), Kuhar et al.
patent: 5413779 (1995-05-01), Kuhar et al.
patent: 5496953 (1996-03-01), Kuhar et al.
Maarten E. A. Reith et al., "Structural Requirements for cocaine congeners to interact with Dopamine and serotonin uptake sites in mouse brain and to induce stereotyped behavior", Biochemical Pharmacology, vol. 35, No. 7, pp. 1123-1129, 1986.
Abraham Philip
Boja John W.
Carroll Frank I.
Kuhar Michael J.
Lewin Anita H.
Dees Jos,e G.
Hartley Michael G.
Research Triangle Institute
LandOfFree
Methods for controlling invertebrate pests using cocaine recepto does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for controlling invertebrate pests using cocaine recepto, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for controlling invertebrate pests using cocaine recepto will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1120364