Substituted liposaccharides useful in the treatment and preventi

Details Substituted liposaccharides useful in the treatment and preventi Substituted liposaccharides useful in the treatment and preventi

1996-06-05

1999-08-10

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 172, 536 179, 53612313, A61K 3170, C13K 500

Patent

active

059359382

ABSTRACT:
Novel substituted liposaccharides useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are methods of preparing these agents and intermediates useful therein.

REFERENCES:
patent: 4495346 (1985-01-01), Anderson et al.
patent: 4987237 (1991-01-01), Myers et al.
patent: 5066794 (1991-11-01), Shiba
patent: 5530113 (1996-06-01), Christ et al.
Bone et al., "Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis", Chest: The Cardiopulmonary J., 101:1644-55 (1992).
Knaus et al., "The Apache III Prognostic System: Risk Prediction of Hospital Mortality for Critically Ill Hospitalized Adults", Chest: The Cardiopulmonary J., 100:1619-36 (1991).
Knaus et al., "Recommendations for Use of Folic Acid to Reduce Number of Spina Bifida Cases and Other Neural Tube Defects", JAMA, 269:1233-41 (1993).
Rose et al., "Agonistic and Antagonistic Activities of Bacterially Derived Rhodobacter Sphaeroides Lipid A: Comparison with Activities of Synthetic Material of the Proposed Structure and Analogs", Infection and Immunity, 63:833-39 (1995).
Ruff et al., "Tumor Necrosis Factor", Lymphokines: A Forum for Immunoregulatory Cell Products; Academic Press 2:235-72 (1981).
Schwartz et al., "Endotoxin Responsiveness and Grain Dust-induced Inflammation in the Lower Respiratory Tract", Am. J. Physiol., 267:l609-17 (1994).
Vogel et al., "BCG-Induced Enhancement of Endotoxin Sensitivity in C3H/HeJ Mice", J. Immunology, 124:2004-2009 (1980).
Takayama et al., Infection and Immunity 57:1336-1338, 1989.

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