Anti-spasmodic substituted quinolizidine and indolizidine compou

Details Anti-spasmodic substituted quinolizidine and indolizidine compou Anti-spasmodic substituted quinolizidine and indolizidine compou

1979-03-01

1980-05-27

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

546112, 546138, A61K 31445, C07D45502, C07D47104

Patent

active

042050740

ABSTRACT:
Phenyl- or thienyl-substituted quinolizidines and indolizidines as well as quaternary salts thereof are disclosed. These compounds are useful as pharmaceutical agents exhibiting strong spasmolytic, anti-ulcer, anti-histaminic and antiemetic activities with minimized side effects such as thirst and dilation of the pupil.
Phenyl- or thienyl-substituted quinolizidine-methanols and indolizidine-methanols which are starting materials of the aforementioned quinolizidine and indolizidine compounds are also useful as having spasmolytic, anti-ulcer, anti-histaminic and anti-emetic activities.

REFERENCES:
Winterfeld et al., Berichte, 90,863 (1957).

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