Human pancreatitis-associated protein

Details Human pancreatitis-associated protein Human pancreatitis-associated protein

1997-03-20

1999-08-10

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 912, 4353201, 4352523, 536 231, 536 234, 536 235, 530 35, C12N 1512, C12N 1511, C12N 1500, C07K 14435

Patent

active

059358130

ABSTRACT:
The present invention provides a novel human C-type lectin (human PAP-2) and polynucleotides which identify and encode human PAP-2. The invention also provides expression vectors, host cells, agonists, antibodies or antagonists. The invention also provides methods for treating or preventing diseases associated with expression of human PAP-2.

REFERENCES:
patent: 5436169 (1995-07-01), Iovanna et al.
Barondes, S.H. et al., "Galectins. Structure and function of a large family of animal lectins." J.Biol.Chem. (1994) 269(33):20807-20810.
Stoolman, L.M., "Adhesion Molecules Controlling Lymphocyte Migration," Cell 56:907-910 (1989).
Drickamer "Ca.sup.2+ -dependent carbohydrate-rocognition domains in animal proteins." Curr.Opin.Struct.Biol. (1993) 3:393-400.
Unno, M. et al., "Structure, chromosomal localization, and expression of mouse reg genes, reg I and reg II." J.Biol.Chem. (1993) 268(21):15974-15982.
Terazono, K. et al., "A novel gene activated in regenerating islets." J.Biol.Chem. (1988) 263(5):2111-2114.
Moriizumi, S. et al., "Isolation, structural determination and expression of a novel reg gene, human regI .beta.." Biochim.Biophys.Acta. (1994) 1217:199-202.
Dusetti, N.J. et al., "Rapid PCR cloning and sequence determination of the rat lithostathine gene." Biochim.Biophys.Acta. (1993) 1174:99-102.
Rouquier, S. et al., "Rat Pancreatic Stone Protein Messenger RNA." J.Biol.Chem. (1991) 266(2):786-791.
de la Monte, S.M. et al., "Enhanced expression of an exocrine pancreatic protein in Alzheimer's disease and the developing human brain." J.Clin.Invest. (1990) 86:1004-1013.
Ozturk, M. et al., "Elevated levels of an exocrine pancreatic secretory protein in Alzheimer disease brain." Proc.Natl.Acad.Sci. (1989) 86:419-423.
Iovanna, J. et al., "Messenger RNA sequence and expression of rat pancreatitis-associated protein, a lectin-related protein overexpressed during acute experimental pancreatitis." J.Biol.Chem. (1991) 266(36):24664-24669.
Orelle, B. et al., "Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases." J.Clin.Invest. (1992) 90:2284-2291.
Itoh, T. et al., "Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP)." Biochim.Biophys.Acta. (1993) 1172:184-186.
Dusetti, N.J. et al., "Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene." Genomics (1994) 19:108-114.
Keim, V. et al., "Characterization of a rat pancreatic secretory protein associated with pancreatitis." Gastroenterology (1991) 100:775-782.
Christa, L. et al., "The human HIP gene overexpressed in primary liver cancer encodes for a C-type carbohydrate binding protein with lactose binding activity." FEBS Letters (1994) 337:114-118.
Lasserre, C. et al., "A novel gene (HIP) activated in human primary liver cancer." Cancer Res. (1992) 52:5089-5095.
Orelle, B. et al. (GI 262369), GenBank Sequence Database (Accession S51768), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.
Orelle, B. et al. (GI 262368), GenBank Sequence Database (Accession S51768), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894.

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