Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-05-12
1999-08-10
Sisson, Bradley L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 911, 435 912, 435810, 536 243, 536 2433, 536 256, C12Q 168, C12P 1934, C07H 2104, C07H 2102
Patent
active
059357878
ABSTRACT:
An assay for detection of a mammalian cell proliferative disorder associated with a hypermutable nucleic acid sequences is provided. The identification of particular hypermutable sequences such as microsatellite loci correlates with a particular cancer, thereby allowing detection of both primary tumors and metastatic sites within a patient.
REFERENCES:
patent: 4800159 (1989-01-01), Mullis et al.
patent: 5075217 (1991-12-01), Weber
patent: 5380645 (1995-01-01), Vogelstein
patent: 5492808 (1996-02-01), De La Chapelle et al.
patent: 5578450 (1996-11-01), Thibodeau et al.
King, et al., A Polymerase Chain Reaction-Based Microsatellite Typing Assay Used for Tumor Cell Line Identification, American Journal of Pathology, vol. 144, No. 3, Mar. 1994, pp. 486-491.
Wang, et al., Brief Report: Polymorphic Microsatellite Markers for the Diagnosis of Graft-Versus-Host Disease, The New England Journal of Medicine, Feb. 10, 1994, vol. 330, No. 6, pp. 398-401.
Noble, et al., A Rapid PCR-Based Method To Distinguish Between Fetal and Maternal Cells in Chorionic Biopsies Using Microsatellite Polymorphisms, Disease Markers, vol. 9, p. 301-306, 1991.
Strand, et al., Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair, Nature, vol. 365, pp. 274-276, Sep. 16, 1993.
Ionov, et al., Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis, Nature, vol. 363, pp. 558-561, Jun. 10, 1993.
Palombo, et al., Mismatch repair and cancer, Nature, vol. 367, p. 417, Feb. 3, 1994.
Peltomaki, et al., Microsatellite Instability is Associated with Tumors That Characterize the Hereditary Non-Polyposis Colorectal Carcinoma Syndrome, Cancer Research, 53, pp. 5853-5855, Dec. 15, 1993.
Peltomaki, et al., Genetic Mapping of a Locus Predisposing to Human Colorectal Cancer, Science, vol. 260, May 7, 1993, pp. 810-819.
Hayashi, et al., Genetic Diagnosis Identifies Occult Lymph Node Metastases Undetectable by the Histopathological Method, Cancer Research, 54, pp. 3853-3856, Jul. 15, 1994.
Thibodeau et alii, Science, vol. 260, May 7, 1993, pp. 816-819.
Hayashi et alii, Cancer Research, vol. 54, 3853-3856, Jul. 15, 1994.
Sidransky et alii, Science, vol. 252, May 3, 1991, pp. 706-709.
Sidransky et alii, Science, vol. 256, Apr. 3, 1992, pp. 102-105.
Peltomaki et alii, Cancer Research, vol. 53, Dec. 15, 1993, 5853-5855.
Hayashi et al., "Genetic Diagnosis Identifies Occult Lymph Node Metastases Undetectable by the Histopathological Method," Cancer Research, 54, 3853-3856, Jul. 5, 1994.
Ionov et al., "Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis," Nature, vol. 363,558-561, Jun. 10, 1993.
Sidransky et al., "Identification of p53 Gene Mutations in Bladder Cancers anbd Urine Samples," Science, vol. 252, pp. 706-709, May. 3, 1991.
Sisson Bradley L.
The Johns Hopkins University
LandOfFree
Detection of hypermutable nucleic acid sequence in tissue does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Detection of hypermutable nucleic acid sequence in tissue, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Detection of hypermutable nucleic acid sequence in tissue will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1119129