Chromatographic apparatus and method

Liquid purification or separation – With alarm – indicator – register – recorder – signal or... – Responsive to fluid flow

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55 67, B01D 1508

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active

042049520

ABSTRACT:
An apparatus and method for increasing the throughput of a chromatographic system by passing several samples in seriatim through tandemly connected first and second chromatographic columns. The eluant from the first column is sampled, or fractionated, and fractions of each of the samples are passed through the second column for further separation. A switching of the sampling valve, disposed between the first and second columns, effects such fractioning. The pumping rate for the second column may be different from that of the first column and allows that two or more sample fractions can occupy the second column concurrently.

REFERENCES:
patent: 3002583 (1961-10-01), Findlay
patent: 3373872 (1968-03-01), Hrdina
patent: 3508880 (1970-04-01), Hrdina
patent: 3897213 (1975-07-01), Stevens
patent: 3918906 (1975-11-01), Small et al.
patent: 4001112 (1977-01-01), Barker
patent: 4054430 (1977-10-01), Valentin et al.
patent: 4070284 (1978-01-01), Fudita et al.
"Two Stage Liquid Chromatograph" by Simmons et al. in Analytical Chemistry, vol. 30, p. 32, 1/1958.
"Gas Chromatography" by Schupp in Technique of Organic Chemistry, vol. XIII, p. 241, 1968.
"Continuous Chromatographic Refining Using a New Compact Chromatographic Machine", by Barker et al. in Journal of Chromatography Science, vol. 7, p. 246, 7/1969.
"Comparisons of Normal Elutions, Coupled Columns, and Solvent Flow or Temperature Programming in Liquid Chromatography" by Snyder in Journal of Chromatography Science, vol. 8, p. 692, 12/1970.

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